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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) in excess of 27, provided they also suffer from weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so when an aid to stopping smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a medical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of 4.1% instead of participants who have been given placebos) during a 12- month period, while a separate study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to shed weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the people that go through it you need to err along the side of caution and allow FDA do its job and demand some investigation be done in order that the public understands the side effects and risks of the medications before we bring them. Keep in mind that drug companies come in business to make money and that they would say anything to keep people on their own medications.

Researchers found out that participants using this drug for a year, dropped a few pounds within a month and have kept the load off through the entire 56 weeks of the study. Contrave is a combination from the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which might make them more potent and safer.

Combo-pilling is the newest fad or also the newest to come under scrutiny and so it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular will be the fact that as of right now there are not any long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise blood pressure level and heartrate, and shouldn't be used in those with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must not be used in patients with uncontrolled high blood pressure levels, along with by you are not heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients on the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

To maintain your most current articles from Wendi, the Indiana Addiction Recovery Examiner, go through the subscribe link at the top of the page to obtain email notification when new content is published. Please leave a comment for any article.

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